Radiation Dosimetry of β-Amyloid Tracers 11C-PiB and 18F-BAY94-9172
نویسندگان
چکیده
منابع مشابه
Plasma Based Markers of [11C] PiB-PET Brain Amyloid Burden
Changes in brain amyloid burden have been shown to relate to Alzheimer's disease pathology, and are believed to precede the development of cognitive decline. There is thus a need for inexpensive and non-invasive screening methods that are able to accurately estimate brain amyloid burden as a marker of Alzheimer's disease. One potential method would involve using demographic information and meas...
متن کاملEvaluation of the biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe [18F]FACT in humans
BACKGROUND The biodistribution and radiation dosimetry of the 18F-labelled amyloid imaging probe ([18F] FACT) was investigated in humans. METHODS Six healthy subjects (three males and three females) were enrolled in this study. An average of 160.8 MBq of [18F] FACT was intravenously administered, and then a series of whole-body PET scans were performed. Nineteen male and 20 female source orga...
متن کاملBiodistribution and radiation dosimetry of 11C-WAY100,635 in humans.
UNLABELLED Serotonin 1A receptors have been implicated in a variety of conditions including depression, suicidal behavior, and aggression. Dose estimates for current human studies are based on data from rat dosimetry studies. We report the biodistribution and dosimetry of the PET serotonin 1A antagonist 11C-WAY100,635 in humans. METHODS PET studies of 6 healthy human volunteers (3 male, 3 fem...
متن کاملRelationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding.
UNLABELLED The purpose of this study was to investigate the potential relationships between cerebrospinal fluid (CSF) measurements of beta-amyloid-1-42 (Abeta(1-42)) and total tau to (11)C-Pittsburgh compound B ((11)C-PiB) and 2-(1-{6-[(2-(18)F-fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene) malononitrile ((18)F-FDDNP) binding as measured using PET. METHODS A total of 37 subjects were inclu...
متن کاملIn vivo visualization of amyloid deposits in the heart with 11C-PIB and PET.
UNLABELLED Cardiac amyloidosis is a differential diagnosis in heart failure and is associated with high mortality. There is currently no noninvasive imaging test available for specific diagnosis. N-[methyl-(11)C]2-(4'-methylamino-phenyl)-6-hydroxybenzothiazole ((11)C-PIB) PET is used in the evaluation of brain amyloidosis. We evaluated the potential use of (11)C-PIB PET in systemic amyloidosis ...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2009
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.108.055756